Neurobiol Dis︱中科院深圳先进院李蕾团队合作揭示蓝斑介导肠道菌群代谢产物吲哚诱发动物焦虑样行为
Neurobiol Dis︱中科院深圳先进院李蕾团队合作揭示蓝斑介导肠道菌群代谢产物吲哚诱发动物焦虑样行为
Recently, the team led by Dr. Lei Li at the Institute of Brain Cognition and Brain Disease / Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, in collaboration with Dr. Sylvie Rabot’s team at the French National Research Institute for Agriculture, Food and Environment (INRAE), published a research article in the neuroscience journal Neurobiology of Disease. The paper, titled “Indole induces anxiety-like behaviour in mice mediated by brainstem locus coeruleus activation,” reports that indole—a microbial metabolite in the gut–brain axis—acts on the locus coeruleus (LC) in the brainstem as a central target. The study reveals that indole exerts its anxiety-modulating effects by activating noradrenergic neurons in the LC, identifying a novel mechanism by which gut-derived signals influence emotional behavior.